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Pan-cancer analysis reveals potential immunological and prognostic roles of COA6 in human cancers and preliminary

Hong Luo1, Zhiyong Wang2

  • 1Department of Oncology, Yancheng Branch of Nanjing Drum Tower Hospital, Yancheng 224001, Jiangsu Province, China.

Cellular Signalling
|February 23, 2024
PubMed
Summary

Cytochrome C oxidase assembly factor 6 (COA6) is a potential diagnostic biomarker and crucial player in the tumor microenvironment across cancers. Suppressing COA6 hinders bladder cancer growth, suggesting therapeutic potential.

Keywords:
Bladder cancerCOA6ImmunotherapyMolecular dockingTumor microenvironmentpan-cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Cytochrome C oxidase assembly factor 6 (COA6) is implicated in cancer progression and shows aberrant expression.
  • Comprehensive analysis of COA6's role in cancer prognosis and the immune microenvironment is lacking.

Purpose of the Study:

  • To conduct a comprehensive analysis of COA6 gene expression abnormalities in cancer.
  • To investigate COA6's impact on prognosis, the immune microenvironment, and therapeutic response.
  • To explore COA6's function in bladder cancer.

Main Methods:

  • Analysis of COA6 gene expression in 33 cancer cases.
  • Assessment of diagnostic and prognostic value, pathway enrichment, and immune microenvironment correlations.
  • In vitro studies on COA6 function in bladder cancer and molecular docking for drug identification.

Main Results:

  • COA6 variations identified, positioning COA6 as a potential cancer diagnostic biomarker.
  • COA6 plays a key role in the pan-cancer tumor microenvironment and correlates with TMB and MSI.
  • Natural small molecule inhibitors targeting COA6 were identified; COA6 suppression inhibited bladder cancer cell growth.

Conclusions:

  • COA6 shows significant potential as a biomarker for predicting cancer prognosis and response to immunotherapy.
  • Further research into COA6's mechanisms in tumor infiltration and therapeutic applications is warranted.