Diagnostic potential of SORT1 gene in coronary artery disease
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated SORT1 gene expression is linked to coronary artery disease (CAD) severity. Higher SORT1 levels in CAD patients may serve as a potential biomarker for disease detection and progression.
Area Of Science
- Cardiovascular Genetics
- Molecular Biology
- Biomarker Discovery
Background
- Genome-wide association studies implicate the SORT1 gene in coronary artery disease (CAD) risk.
- Sortilin protein influences LDL absorption, cellular development, and macrophage atherosclerosis.
Purpose Of The Study
- To investigate SORT1 gene expression in CAD patients.
- To assess the predictive value of SORT1 expression for CAD severity.
Main Methods
- Case-control study involving 200 CAD patients and 200 healthy controls.
- Quantitative real-time PCR, Sandwich ELISA, and Western blotting used to measure SORT1 mRNA and protein levels.
Main Results
- CAD patients showed significantly higher SORT1 gene and protein expression compared to controls.
- SORT1 expression positively correlated with coronary artery stenosis severity, number of diseased vessels, and diabetes presence.
- Receiver Operating Characteristic (ROC) curve analysis demonstrated strong discrimination between CAD and control groups based on SORT1 expression.
Conclusions
- Elevated SORT1 gene expression is associated with various CAD syndromes.
- SORT1 may serve as a potential diagnostic biomarker for coronary artery disease.
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