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Chitosan nanocarriers for non-coding RNA therapeutics: A review
S Karthik1, Sahithya Mohan1, Induja Magesh1
1Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India.
International Journal of Biological Macromolecules
|February 23, 2024
Summary
Chitosan nanocarriers offer a promising solution for delivering non-coding RNA (ncRNA) therapeutics. These nanocarriers protect ncRNAs and enable targeted delivery for treating various diseases.
Area of Science:
- Biomaterials Science
- RNA Therapeutics
- Nanotechnology
Background:
- Non-coding RNA (ncRNA) therapies show potential for treating infections, cancer, neurological disorders, and bone abnormalities.
- Delivery of ncRNAs to specific cellular targets remains a significant challenge, limiting their therapeutic efficacy.
- Chitosan (CS), a biocompatible cationic polymer, can form stable complexes with negatively charged ncRNAs, presenting a viable option for nanocarrier development.
Purpose of the Study:
- To review recent advancements in chitosan (CS)-based nanocarriers for non-coding RNA (ncRNA) therapeutics.
- To discuss the synthesis, design, and application of CS nanocarriers in treating various diseases.
- To identify challenges and limitations associated with CS-based nanocarriers and propose strategies for improvement.
Main Methods:
- Literature review of recent developments in chitosan nanocarrier synthesis and design.
- Analysis of CS nanocarrier applications in ncRNA therapeutics for diverse diseases.
- Discussion of challenges and future strategies for CS-based ncRNA delivery systems.
Main Results:
- Chitosan nanocarriers effectively protect ncRNAs from degradation.
- Surface modifications and controlled release profiles enable targeted delivery of ncRNAs.
- CS-based nanocarriers demonstrate potential in various therapeutic applications.
Conclusions:
- Chitosan nanocarriers represent a promising platform for advancing ncRNA therapeutics.
- Further research into overcoming current limitations can enhance the clinical translation of CS-based ncRNA delivery systems.
- Optimized CS nanocarriers can improve the efficacy and specificity of ncRNA-based treatments for numerous diseases.
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