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Methanol interference in LC-MS/MS vitamin D: need for lot-to-lot verification

Wan Ling Cheng1, Suru Chew1, Sunil Kumar Sethi1

  • 1Department of Laboratory Medicine, National University Hospital, Singapore.

Pathology
|February 23, 2024
PubMed
Abstract

No abstract available in PubMed .

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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