Association of the triglyceride-glucose index with the occurrence and recurrence of colorectal adenomas: a...

Area of Science:

• Gastroenterology
• Metabolic Syndrome
• Oncology

Background:

• Colorectal adenoma (CRA) resection prevents cancer, but recurrence is frequent.
• The triglyceride-glucose (TyG) index is a marker of insulin resistance.
• Understanding factors associated with CRA recurrence is crucial for patient management.

Purpose of the Study:

• To investigate the association between the triglyceride-glucose (TyG) index and the occurrence of colorectal adenomas (CRAs).
• To evaluate the relationship between the TyG index and the recurrence of CRAs after resection.

Main Methods:

• Analysis of data from 3392 participants in China (2020-2022).
• Logistic regression and restricted cubic splines used to assess TyG index associations.
• Receiver operating characteristic (ROC) curve analysis evaluated predictive power for recurrence.

Main Results:

• Elevated TyG index was an independent risk factor for both CRA occurrence and recurrence.
• Higher TyG index quartiles correlated with increased odds of adenoma occurrence and recurrence.
• The TyG index demonstrated good predictive efficacy for identifying CRA recurrence, especially in patients with multiple adenomas.

Conclusions:

• Increased TyG index is associated with a higher risk of CRA occurrence and recurrence.
• The association between TyG index and CRA recurrence is stronger than its association with occurrence.
• The TyG index may serve as a valuable biomarker for predicting CRA recurrence.