Clinical characteristics and prognostic analysis of postoperative recurrence or metastasis of low-risk gastrointestinal stromal tumors
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View abstract on PubMed
Summary
This summary is machine-generated.Low-risk gastrointestinal stromal tumors (GISTs) can recur. Tumor location, size, and Ki-67 index are key predictors of recurrence, guiding personalized follow-up for these GIST patients.
Area Of Science
- Oncology
- Gastroenterology
- Surgical Pathology
Background
- Gastrointestinal stromal tumors (GISTs) represent the most frequent mesenchymal neoplasms within the digestive tract.
- Understanding recurrence patterns in low-risk GISTs is crucial for tailored postoperative management.
Purpose Of The Study
- To identify clinical characteristics and prognostic factors associated with postoperative recurrence or metastasis in patients diagnosed with low-risk GISTs.
- To establish a basis for individualized treatment strategies for low-risk GIST patients exhibiting a notable risk of recurrence.
Main Methods
- Retrospective analysis of clinicopathological and follow-up data from 282 low-risk GIST patients who underwent surgical resection.
- Exclusion of patients treated with imatinib; application of univariate and multivariate Cox analysis and survival curves.
Main Results
- 14 out of 282 (4.96%) low-risk GIST patients experienced recurrence or metastasis.
- Tumor size, primary site, resection type, Ki67 index, NLR, and CD34 expression correlated with recurrence (P < 0.05).
- Multivariate analysis identified primary site, tumor size, and Ki67 index as independent risk factors for recurrence; non-gastric location, larger tumors, and high Ki67 predicted poor progression-free survival (PFS).
Conclusions
- Tumor location, size, and Ki-67 index are independent predictors of postoperative recurrence and metastasis in low-risk GISTs.
- Integrating these factors with the 2008 modified NIH recurrence risk grading system can refine prognostic evaluation.
- This approach facilitates personalized postoperative surveillance and management recommendations for patients with low-risk GISTs.
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