The effect of oral supplementation of Paricalcitol on C-reactive protein levels in chronic kidney disease patients: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials
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View abstract on PubMed
Summary
This summary is machine-generated.Oral paricalcitol supplementation significantly reduces C-reactive protein levels in chronic kidney disease (CKD) patients. This finding suggests a potential therapeutic benefit for managing CKD progression.
Area Of Science
- Nephrology
- Pharmacology
Background
- Investigates the impact of oral paricalcitol on C-reactive protein (CRP) levels in chronic kidney disease (CKD).
- Addresses inconsistent findings from previous studies on paricalcitol's effect on CRP in CKD patients.
Approach
- Systematic review and meta-analysis of randomized clinical trials.
- Searched MEDLINE, Scopus, and Web of Science databases up to January 2023.
- Utilized a random effect model to calculate weighted mean differences (WMD) and 95% confidence intervals (CI).
Key Points
- Included 4 studies (6 arms) from an initial 182 articles.
- Pooled analysis revealed a significant decrease in CRP levels post-paricalcitol supplementation (WMD: -2.55 mg/L).
- Observed significant heterogeneity among the included studies (I² = 66.3%, P = 0.01).
Conclusions
- Oral paricalcitol supplementation effectively reduces CRP levels in CKD patients.
- This reduction in CRP may play a role in preventing the progression of chronic kidney disease.
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