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Protein C activity in renal disease.
Thrombosis Research
|May 1, 1985
Summary
Protein C activity is normal in nephrotic syndrome but significantly decreased in renal insufficiency and terminal uremia. Reduced protein C may increase thrombotic risk in kidney disease patients.
Area of Science:
- Nephrology
- Hematology
- Biochemistry
Background:
- Renal diseases and uremia are associated with an increased risk of thrombosis.
- The role of coagulation factors, such as Protein C, in this thrombotic tendency is not fully understood.
Purpose of the Study:
- To investigate Protein C activity in patients with various stages of renal disease.
- To determine if reduced Protein C activity correlates with the severity of renal failure.
Main Methods:
- Protein C activity was measured in 19 healthy controls and 52 patients with renal diseases.
- Patients were categorized into three groups: nephrotic syndrome, renal insufficiency, and terminal uremia requiring dialysis.
Main Results:
- Protein C levels were normal in patients with nephrotic syndrome.
- A significant decrease in Protein C activity was observed in patients with renal insufficiency and terminal uremia.
- A correlation between declining Protein C activity and progressive renal failure was suggested.
Conclusions:
- Reduced Protein C activity is associated with advanced renal insufficiency and uremia.
- Decreased Protein C may contribute to the heightened thrombotic risk in patients with kidney disease.