Assessing peptic ulcer risk with the HAMPROW score in the general Chinese population

Area of Science:

• Gastroenterology
• Internal Medicine
• Preventive Medicine

Background:

• Peptic ulcers (PUs) pose a risk for gastrointestinal bleeding, particularly during antiplatelet therapy.
• Timely identification of high-risk individuals is crucial for effective prevention strategies.
• A validated risk assessment model is needed for the general Chinese population.

Purpose of the Study:

• To identify independent risk factors for peptic ulcers in the Chinese population.
• To develop and validate a predictive model for peptic ulcer risk.
• To facilitate early detection and prevention of gastrointestinal bleeding.

Main Methods:

• Prospective study of 902 patients undergoing gastroscopy (April 2019-May 2022).
• LASSO-derived logistic regression analysis to identify risk factors and develop the HAMPROW score.
• Temporal validation of the developed risk score.

Main Results:

• Seven independent risk factors identified: male sex, white blood cell count, red blood cell count, globulin level, albumin level, pepsinogen I level, and positive Helicobacter pylori antibody.
• The HAMPROW score demonstrated strong predictive ability with AUCs of 0.854 (development) and 0.833 (validation).
• The score effectively predicts peptic ulcer risk in the Chinese population.

Conclusions:

• The HAMPROW score is a reliable tool for screening peptic ulcer risk in the general Chinese population.
• This model supports personalized early detection of high-risk individuals.
• Early risk assessment can help prevent gastrointestinal bleeding associated with antiplatelet therapy.