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Could Tumor Necrosis Factor Serve as a Marker for Cardiovascular Risk Factors and Left Ventricular Hypertrophy in
Marta Białecka1, Violetta Dziedziejko2, Krzysztof Safranow2
1Department of Internal Diseases and Hematology, Military Medical National Research Institute, Szaserów 128, 04-349 Warszawa, Poland.
Insights
Elevated levels of Tumor Necrosis Factor (TNF) correlate with metabolic syndrome components and cardiovascular disease risk factors in young patients with coronary artery disease (CAD). TNF may indicate impaired diastolic function but is not a substitute for echocardiography.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Metabolic Disorders
Background:
- Cardiomyocyte production of Tumor Necrosis Factor (TNF), a pro-inflammatory cytokine, contributes to myocardial metabolic disorders.
- Coronary Artery Disease (CAD) in younger individuals presents unique challenges in risk assessment.
Purpose of the Study:
- To investigate the association between plasma TNF levels and cardiovascular disease risk factors.
- To explore the relationship between TNF and cardiac morphology parameters in young CAD patients.
Main Methods:
- Plasma TNF concentrations were quantified using ELISA assays.
- Echocardiography and electrocardiography were performed on all participants.
- The study included 75 men (≤50 years) and 25 women (≤55 years).
Main Results:
- Positive correlations were found between TNF and BMI, weight, waist, and hip circumference.
- Negative correlations linked TNF to HDL and ApoA levels; positive correlations with ApoB/ApoA1 ratio, Apo B, IL6, LDL, and TG.
- Higher TNF levels were associated with metabolic syndrome components, including dyslipidemia, and potentially impaired diastolic function.
Conclusions:
- Plasma TNF levels show a significant association with metabolic syndrome and dyslipidemia in young CAD patients.
- TNF may serve as a diagnostic marker for certain risks in CAD patients.
- TNF measurement is not a suitable surrogate for echocardiography in assessing cardiac function.
Abstract:
Introduction: Tumor necrosis factor (TNF), a pro-inflammatory cytokine, can be produced by cardiomyocytes, leading to metabolic disorders in the myocardium. The objective of this study was to assess the relationship between plasma levels of the TNF cytokine and the presence of known biochemical and clinical risk factors for cardiovascular disease, along with the parameters of cardiac morphology in patients diagnosed with coronary artery disease (CAD) at a young age. Materials and Methods: The study group included 75 men aged up to 50 years and 25 women aged up to 55 years. The plasma TNF concentration was measured by use of the ELISA assay. Echocardiography and electrocardiographic examinations were performed in all patients. Results: We observed positive correlations for TNF with the BMI ratio, weight, waist and hip circumference. We also found negative correlations for TNF with HDL levels and ApoA concentrations, and positive correlations with the ApoB/ApoA1 ratio, Apo B, IL6, LDL and TG concentrations. These results suggest an association between higher plasma TNF concentrations and components of metabolic syndrome, including dyslipidemia. TNF may be a potential risk factor for impaired diastolic function. Conclusions: While TNF may be useful for diagnosing certain risks in CAD patients, the TNF measurement cannot be used as a surrogate test for echocardiography.
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