Chaenomeles sinensis Extract Ameliorates Ovalbumin-Induced Allergic Rhinitis by Inhibiting the IL-33/ST2 Axis and...

Area of Science:

• Immunology
• Pharmacology
• Traditional Medicine

Background:

• Traditional use of Chaenomeles sinensis for inflammation, hypertension, and mutagenesis.
• Limited research on Chaenomeles sinensis extract (CSE) effects on allergic rhinitis (AR).

Purpose of the Study:

• Investigate the therapeutic potential of CSE on AR.
• Elucidate the underlying mechanisms of CSE in an ovalbumin-induced AR mouse model.

Main Methods:

• Ovalbumin (OVA)-induced AR mouse model.
• Assessment of OVA-specific immunoglobulins (IgE, IgG2a), nasal symptoms, cytokine profiles (Th1/Th2), inflammatory cell infiltration, and nasal histopathology.
• Evaluation of epithelial permeability and E-cadherin expression.
• Analysis of IL-33/ST2 signaling pathway.

Main Results:

• CSE suppressed OVA-specific IgE and ameliorated Th2 cytokine production, while increasing Th1 cytokines.
• CSE treatment inhibited IL-33/ST2 signaling and reversed OVA-induced epithelial barrier dysfunction by upregulating E-cadherin.
• CSE administration reduced inflammatory cell infiltration and improved nasal and lung histopathology.

Conclusions:

• CSE demonstrates significant therapeutic efficacy in controlling allergic responses and suppressing airway inflammation in AR.
• CSE holds potential as a treatment for allergic rhinitis and related airway diseases.