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Updated: Jul 2, 2025
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
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The Association between Coagulation and Atrial Fibrillation
Saira Rafaqat1, Sanja Gluscevic2, Dimitrios Patoulias3
1Department of Zoology (Molecular Physiology), Lahore College for Women University, Lahore 54600, Punjab, Pakistan.
Biomedicines
|February 24, 2024
Summary
Coagulation factors and markers are linked to atrial fibrillation (AF) development. This review details how fibrinogen, prothrombin, and platelet activation contribute to AF pathogenesis.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Biochemistry
Background:
- Numerous coagulation factors and markers are documented in scientific literature.
- Elevated coagulation factor levels correlate with existing and new atrial fibrillation (AF) diagnoses.
Purpose of the Study:
- To summarize the role of coagulation in the pathogenesis of atrial fibrillation (AF).
- To highlight key coagulation components involved in AF development.
Main Methods:
- Literature review summarizing existing research on coagulation and AF.
- Identification and discussion of specific coagulation factors and markers implicated in AF pathogenesis.
Main Results:
- Coagulation irregularities are significant contributors to the pathogenesis of AF.
- Key factors include fibrinogen, fibrin, prothrombin, thrombomodulin, soluble urokinase plasminogen activator receptor, von Willebrand factor, P-selectin, D-dimer, and plasminogen activator inhibitor-1.
- Platelet activation is also a crucial element in AF pathogenesis.
Conclusions:
- Coagulation system dysregulation is a critical factor in the development of atrial fibrillation.
- Understanding these mechanisms can inform future therapeutic strategies for AF.
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