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Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement
Marius Mitrache1,2, Dana Terzea1,3, Anca Sirbu1,2
1Endocrinology Department, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Biomedicines
|February 24, 2024
Summary
Primary thyroid mucoepidermoid carcinoma (MEC) is rare. This case highlights an aggressive presentation of thyroid MEC with metastasis, emphasizing the need for multidisciplinary management despite generally indolent behavior.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Mucoepidermoid carcinomas (MECs) are the most common salivary gland malignancies.
- Primary thyroid MECs are rare, comprising <0.5% of thyroid tumors.
- Typically indolent, thyroid MECs can present aggressively.
Observation:
- A 67-year-old patient presented with primary thyroid MEC.
- The tumor exhibited aggressive behavior with extensive pulmonary metastasis.
- The patient experienced rapid clinical deterioration.
Findings:
- Thyroid MECs, though often indolent, can have a poor prognosis.
- Aggressive thyroid MEC can lead to rapid progression and mortality.
- Optimal treatment for aggressive or metastatic thyroid MEC remains undefined.
Implications:
- Highlights the importance of considering rare malignancies in thyroid pathology.
- Underscores the need for individualized, multidisciplinary treatment approaches for aggressive thyroid MEC.
- Suggests further research into the behavior and management of primary thyroid MECs is warranted.
