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Published on: October 2, 2020
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Association between Serum GDF-15 and Cognitive Dysfunction in Hemodialysis Patients.
Hae Ri Kim1, Moo Jun Kim1, Jae Wan Jeon1
1Department of Nephrology, Chungnam National University Sejong Hospital, Sejong 30099, Republic of Korea.
Biomedicines
|February 24, 2024
Summary
Serum growth differentiation factor 15 (GDF-15) is elevated in patients with cognitive dysfunction undergoing hemodialysis. Higher GDF-15 levels may indicate an increased risk, suggesting its potential as a screening marker.
Area of Science:
- Nephrology
- Neurology
- Biochemistry
Background:
- Cognitive dysfunction is prevalent in end-stage renal disease (ESRD) patients on hemodialysis.
- Early detection of cognitive decline is crucial in this population.
- Serum markers reflecting cognitive function are of increasing research interest.
Purpose of the Study:
- To investigate the association between serum growth differentiation factor 15 (GDF-15) and cognitive dysfunction in hemodialysis patients.
- To evaluate GDF-15 as a potential biomarker for cognitive impairment in this cohort.
Main Methods:
- Retrospective analysis of 92 hemodialysis patients (age ≥ 18).
- Cognitive function assessed using the Korean version of the Mini-Mental Status Examination (K-MMSE).
- Serum GDF-15 levels measured and correlated with K-MMSE scores.
Main Results:
- Patients with cognitive dysfunction (K-MMSE < 24) exhibited significantly higher serum GDF-15 levels (7500.42 pg/mL, p=0.001).
- Logistic regression identified elevated GDF-15 (>5408.33 pg/mL) as a risk factor for cognitive dysfunction.
- In vitro studies showed indoxyl sulfate increased GDF-15 expression and decreased cell survival.
Conclusions:
- Serum GDF-15 is significantly associated with cognitive dysfunction in hemodialysis patients.
- GDF-15 may serve as a valuable and accessible screening tool for cognitive impairment in this clinical setting.
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