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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Current and Emerging Diagnostic, Prognostic, and Predictive Biomarkers in Head and Neck Cancer
Hänel W Eberly1, Bao Y Sciscent1, F Jeffrey Lorenz1
1Department of Otolaryngology Head and Neck Surgery, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA 17033, USA.
Abstract:
Head and neck cancers (HNC) are a biologically diverse set of cancers that are responsible for over 660,000 new diagnoses each year. Current therapies for HNC require a comprehensive, multimodal approach encompassing resection, radiation therapy, and systemic therapy. With an increased understanding of the mechanisms behind HNC, there has been growing interest in more accurate prognostic indicators of disease, effective post-treatment surveillance, and individualized treatments. This chapter will highlight the commonly used and studied biomarkers in head and neck squamous cell carcinoma.
Insights
Biomarkers are crucial for improving prognostics, surveillance, and personalized treatments in head and neck cancers (HNC). This chapter reviews key biomarkers for head and neck squamous cell carcinoma.
Area of Science:
- Oncology
- Biomarker Research
Background:
- Head and neck cancers (HNC) represent a diverse group of malignancies with over 660,000 new cases annually.
- Current HNC treatment involves a multimodal strategy including surgery, radiation, and systemic therapy.
- Advances in understanding HNC mechanisms drive the need for better prognostic tools and personalized medicine.
Purpose of the Study:
- To review commonly used and studied biomarkers in head and neck squamous cell carcinoma.
- To highlight the role of biomarkers in improving prognostic accuracy for HNC.
- To discuss the application of biomarkers in post-treatment surveillance and individualized HNC therapy.
Main Methods:
- Literature review of established and emerging biomarkers for head and neck squamous cell carcinoma.
- Analysis of biomarker utility in predicting HNC outcomes.
- Synthesis of current research on biomarkers for HNC management.
Main Results:
- Identified key biomarkers frequently investigated in head and neck squamous cell carcinoma.
- Emphasized the potential of specific biomarkers to enhance prognostic capabilities.
- Underscored the evolving role of biomarkers in tailoring HNC treatment strategies.
Conclusions:
- Biomarkers are essential for advancing the management of head and neck squamous cell carcinoma.
- Further research into biomarkers will facilitate more accurate prognostication and personalized HNC care.
- The integration of biomarkers promises improved outcomes for patients with head and neck cancers.
