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Updated: Jun 20, 2026

Biomechanical Testing of Murine Tendons
Published on: October 15, 2019
A Comprehensive Review of Muscle-Tendon Junction: Structure, Function, Injury and Repair
Siqi Tong1,2, Yuzhi Sun2,3, Baian Kuang1,2
1School of Medicine, Southeast University, Nanjing 210009, China.
Abstract:
The muscle-tendon junction (MTJ) is a highly specific tissue interface where the muscle's fascia intersects with the extracellular matrix of the tendon. The MTJ functions as the particular structure facilitating the transmission of force from contractive muscle fibers to the skeletal system, enabling movement. Considering that the MTJ is continuously exposed to constant mechanical forces during physical activity, it is susceptible to injuries. Ruptures at the MTJ often accompany damage to both tendon and muscle tissues. In this review, we attempt to provide a precise definition of the MTJ, describe its subtle structure in detail, and introduce therapeutic approaches related to MTJ tissue engineering. We hope that our detailed illustration of the MTJ and summary of the representative research achievements will help researchers gain a deeper understanding of the MTJ and inspire fresh insights and breakthroughs for future research.
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