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Mechanisms of Myocardial Edema Development in CVD Pathophysiology

Diana G Kiseleva1,2, Tatiana V Kirichenko2,3, Yuliya V Markina2

  • 1Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.

Biomedicines
|February 24, 2024
PubMed

Insights

Myocardial edema, excess fluid in heart muscle, worsens cardiovascular disease. Understanding its molecular and cellular mechanisms may reveal new diagnostic and therapeutic targets.

Area of Science:

  • Cardiovascular Science
  • Cellular Biology
  • Molecular Medicine

Background:

  • Myocardial edema is fluid accumulation in the heart muscle, linked to capillary permeability, glycocalyx charge, and lymphatic drainage.
  • It is increasingly recognized not just as a complication but as a driver of cardiovascular disease severity and adverse outcomes.

Purpose of the Study:

  • To review the molecular and cellular mechanisms underlying myocardial edema development.
  • To identify potential therapeutic targets for managing myocardial edema.

Main Methods:

  • Comprehensive literature review of articles indexed in PubMed up to January 2024.
  • Focus on molecular, genetic, and mechanical changes in the myocardium during edema.

Main Results:

  • Detailed description of the primary molecular and cellular pathways contributing to myocardial edema.
  • Identification of key factors influencing fluid accumulation and cardiac dysfunction.

Conclusions:

  • Elucidating myocardial edema mechanisms is crucial for advancing cardiovascular disease treatment.
  • Targeting specific molecular and cellular pathways offers promising avenues for novel therapies.

Keywords:
cardiomyocytescardiovascular diseasesmyocardial edemamyocardial fluid flow

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