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Arteriography in leprosy.

B R Agrawal, R I Agrawal

    Indian Journal of Leprosy
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Leprosy patients exhibit significant vascular changes in their hands and feet, including smooth tapering and vessel occlusion. These arterial abnormalities likely cause decreased blood flow, leading to deformities and ulcers in leprosy.

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    Area of Science:

    • Vascular Medicine
    • Infectious Diseases
    • Dermatology

    Background:

    • Leprosy is a chronic infectious disease primarily affecting peripheral nerves and skin.
    • Vascular complications in leprosy, particularly in the extremities, can lead to significant morbidity, including deformities and ulcerations.

    Purpose of the Study:

    • To investigate the arterial vascular patterns in the hands and feet of leprosy patients.
    • To correlate angiographic findings with muscle biopsy results and their potential role in leprosy-related complications.

    Main Methods:

    • Percutaneous arteriography was performed on 26 leprosy patients to visualize limb vasculature.
    • Muscle biopsy samples were obtained from the same patients for histological examination.

    Main Results:

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    • All arteriograms revealed abnormal vascular findings, including smooth tapering, absent collaterals, arterial occlusion, and vessel tortuosity.
    • 82% of cases showed moderate to severe vascular changes.
    • Muscle biopsies indicated vascular thickening, perivascular granuloma, and lymphocytic infiltration.

    Conclusions:

    • Significant arterial abnormalities are prevalent in leprosy patients, affecting blood flow to the extremities.
    • Reduced distal blood flow (ischemia) is a probable cause of deformities and ulcerations in leprosy.
    • Histopathological findings in muscle tissue may explain the observed angiographic changes and their link to trophic ulceration.