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Related Experiment Video

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Perioperative Platelet Count Ratio Predicts Long-Term Survival after Left Pancreatectomy and Splenectomy for

Ido Nachmany1, Hallbera Gudmundsdottir2, Hila Meiri1

  • 1Department of General Surgery and Transplantation, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv 52621, Israel.

Journal of Clinical Medicine
|February 24, 2024
PubMed
Summary

Post-splenectomy thrombocytosis, measured by perioperative platelet count ratio (PPR), is a significant prognostic biomarker for overall survival in pancreatic adenocarcinoma patients undergoing left pancreatectomy.

Keywords:
biomarkerdistal pancreatectomythrombocytosis

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Hematology

Background:

  • Prognostic value of platelet characteristics in pancreatic ductal adenocarcinoma (PDAC) is not well-established.
  • Investigating post-splenectomy thrombocytosis as a prognostic factor in PDAC.

Purpose of the Study:

  • To assess the prognostic ability of perioperative platelet count ratio (PPR) in patients undergoing left pancreatectomy for PDAC.
  • To determine if PPR can predict long-term outcomes after PDAC surgery.

Main Methods:

  • Retrospective analysis of 106 patients who underwent left pancreatectomy for PDAC (November 2008 - October 2022).
  • Calculated PPR as the ratio of maximum post-operative to pre-operative platelet count.
  • Compared outcomes with a cohort of 245 patients who underwent pancreaticoduodenectomy for PDAC.

Main Results:

  • Median PPR in left pancreatectomy patients was 1.4; 46 had PPR ≥ 1.5, 60 had PPR < 1.5.
  • Patients with PPR ≥ 1.5 had significantly longer overall survival (40 months vs. 20 months, p < 0.001).
  • PPR < 1.5 was a strong predictor of worse overall survival (HR 2.24, p = 0.008) in multivariate analysis. PPR did not predict survival in pancreaticoduodenectomy patients.

Conclusions:

  • Perioperative platelet count ratio (PPR) serves as a valuable biomarker for predicting overall survival after left pancreatectomy for PDAC.
  • Further research is needed to validate these findings and their clinical implications.