Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial
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View abstract on PubMed
Summary
This summary is machine-generated.Supplementing with formulated Palmitoylethanolamide (PEA) significantly boosted serum BDNF levels and improved memory performance in healthy adults. This suggests PEA is a promising intervention for enhancing cognitive health.
Area Of Science
- Neuroscience
- Nutritional Science
- Human Physiology
Background
- Palmitoylethanolamide (PEA) is an endogenous lipid mediator with endocannabinoid-like properties.
- PEA is naturally synthesized in the body and present in certain foods.
- Investigating formulated PEA for cognitive health benefits is warranted.
Purpose Of The Study
- To evaluate the impact of a bioavailable formulated Palmitoylethanolamide (PEA) on serum Brain-Derived Neurotrophic Factor (BDNF) levels.
- To assess the effects of formulated PEA on cognitive function parameters in healthy adults.
- To explore the potential of formulated PEA as a cognitive enhancement intervention.
Main Methods
- A 6-week randomized, double-blind, placebo-controlled, cross-over trial.
- Participants (n=39) received 700 mg/day of formulated PEA or placebo.
- Cognitive tests and serum BDNF measurements (immunoassay) were conducted pre- and post-intervention.
Main Results
- Significant increase in serum BDNF levels post-PEA supplementation (p=0.0057, d=0.62).
- Improved memory performance observed with PEA, indicated by better first success (p=0.142, d=0.54) and fewer errors (p=0.0287, d=-0.47) on the Paired Associates Learning test.
- Levagen+® PEA demonstrated a direct beneficial effect on memory and neurotrophic markers.
Conclusions
- This study is the first to demonstrate Levagen+® PEA's direct positive effects on memory and serum BDNF.
- Formulated PEA supplementation shows potential for enhancing cognitive health.
- PEA may serve as an innovative and practical approach for cognitive function improvement.
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