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Updated: Jun 22, 2026
10:33
Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
20.8K
Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization
Iriczalli Cruz-Maya1, Carmine Schiavone2,3, Rosalia Ferraro2,4
1Institute for Polymers, Composites and Biomaterials, National Research Council, 80125 Naples, Italy.
Pharmaceutics
|February 24, 2024
Summary
This study introduces electro-fluid dynamic atomization (EFDA) to create core-shell monophasic particles (CSMp) for advanced drug delivery. Optimized particle characteristics allow precise control over drug release profiles, enhancing therapeutic efficiency.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Biomedical Engineering
Background:
- Drug delivery systems require innovation for improved therapeutic outcomes.
- Electro-fluid dynamic atomization (EFDA) offers a novel fabrication method for advanced particle structures.
Purpose of the Study:
- To fabricate core-shell monophasic particles (CSMp) using EFDA from sodium alginate.
- To investigate the influence of material properties and process conditions on CSMp morphology.
- To develop a predictive model for simulating drug release kinetics from these particles.
Main Methods:
- Fabrication of CSMp using electro-fluid dynamic atomization (EFDA).
- Characterization of particle morphology and relation to material properties.
- Development of a mathematical model for release kinetics simulation using transport and rheological models.
- Assessment of diffusion properties of small molecules (sodium diclofenac) and gel formulations.
Main Results:
- Successful fabrication of CSMp with tunable morphological characteristics.
- Identification of external shell thickness and diffusivity ratios as key independent parameters for drug release control.
- Development of a predictive model for evaluating drug delivery efficiency.
Conclusions:
- EFDA is a viable technique for fabricating CSMp with potential in drug delivery.
- Precise control over drug release profiles can be achieved by manipulating particle characteristics.
- This research provides a pathway for developing enhanced drug delivery systems with tailored release kinetics.
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