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Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
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Chitosan and Anionic Solubility Enhancer Sulfobutylether-β-Cyclodextrin-Based Nanoparticles as Dexamethasone
Giuseppe Francesco Racaniello1, Gennaro Balenzano1, Ilaria Arduino1
1Department of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.
Pharmaceutics
|February 24, 2024
Summary
New mucoadhesive nanoparticles improve dexamethasone eye drop delivery for post-surgery inflammation. This innovative drug delivery system enhances corneal residence time and drug bioavailability, offering a better treatment for ocular anterior segment diseases.
Area of Science:
- Ophthalmology
- Materials Science
- Nanotechnology
Background:
- Cataract surgery is increasing, leading to ocular anterior segment (AS) inflammation.
- Current dexamethasone (DEX) eye drops require frequent administration, posing challenges.
- Improved drug delivery is needed to enhance therapeutic outcomes for AS inflammatory conditions.
Purpose of the Study:
- To develop mucoadhesive nanoparticles (NPs) for sustained ocular delivery of dexamethasone (DEX).
- To enhance DEX solubility, bioavailability, and corneal residence time.
- To create a safe and effective drug delivery system for post-cataract surgery inflammation.
Main Methods:
- Formulation of NPs using chitosan (CS) and sulfobutylether-β-cyclodextrin (SBE-β-CD) via ionotropic gelation.
- Characterization of inclusion complex formation using phase solubility, Job's plot, and transport studies.
- Evaluation of DEX-loaded NPs for residence time, release profile, permeability, and safety on animal mucosa.
Main Results:
- CS/SBE-β-CD NPs demonstrated suitable characteristics for drug loading.
- DEX-loaded NPs showed prolonged residence time on ocular mucosa.
- Enhanced drug permeability and sustained release profile were observed.
- Developed NPs exhibited no significant irritation or toxicity.
Conclusions:
- Mucoadhesive CS/SBE-β-CD NPs are an effective system for ocular drug delivery.
- The developed NPs improve DEX bioavailability and corneal penetration.
- This innovative system offers a promising alternative for treating inflammatory AS diseases.
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