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Oncogenic Potential of Replication Factor C Subunit 4: Correlations with Tumor Progression and Assessment of

Muhammad Alaa Eldeen1, Farag Mamdouh2, Waleed K Abdulsahib3

  • 1Cell Biology, Histology & Genetics Division, Zoology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.

Pharmaceuticals (Basel, Switzerland)
|February 24, 2024
PubMed

Insights

Replication Factor C Subunit 4 (RFC4) is upregulated in many cancers, correlating with poor patient outcomes. This oncogene impacts the tumor microenvironment and shows potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Replication Factor C Subunit 4 (RFC4) is an oncogene implicated in human cancers.
  • Its expression patterns and tumor tissue function require further investigation across diverse cancer types.

Purpose of the Study:

  • To analyze RFC4 as a potential oncogene and therapeutic target using bioinformatics tools.
  • To determine RFC4 expression levels and their correlation with tumor characteristics and patient survival.
  • To investigate RFC4's role in the tumor microenvironment (TME) and its association with immune cell infiltration and immunological checkpoints.

Main Methods:

  • Utilized various bioinformatics tools for comprehensive RFC4 analysis.
  • Examined RFC4 expression, genetic alterations, and epigenetic methylation across multiple human tumor types.
  • Assessed RFC4's impact on TME immune cell infiltration and immunological checkpoints.
  • Screened for pharmacological compounds that inhibit RFC4.

Main Results:

  • RFC4 is upregulated in several human tumor types.
  • Elevated RFC4 expression is associated with poor prognoses in many cancers.
  • RFC4 significantly influences the TME, affecting immune cell populations.
  • RFC4 demonstrates connections with immunological checkpoints, suggesting involvement in carcinogenesis.

Conclusions:

  • RFC4 plays a significant role in cancer development and progression.
  • RFC4 serves as a potential prognostic biomarker in numerous cancers.
  • Targeting RFC4 with pharmacological agents presents a promising anti-cancer therapeutic strategy.
Keywords:
RFC4carcinogenesisoncogenepan-cancerprognosis

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