How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

Area of Science:

• Medicinal Chemistry
• Green Chemistry
• Sustainable Pharmaceutical Development

Background:

• The pharmaceutical industry faces significant environmental challenges due to high pollution and E-factors.
• There is a growing need for sustainable and eco-friendly processes in drug design and synthesis.
• Traditional organic solvents contribute to the environmental burden of pharmaceutical manufacturing.

Purpose of the Study:

• To review the role and applications of deep eutectic systems (DESs) in drug discovery.
• To highlight DESs as greener alternatives to conventional solvents.
• To explore the use of DESs in both biocatalytic and traditional organic chemical reactions for drug synthesis.

Main Methods:

• Review of literature on deep eutectic systems in medicinal chemistry.
• Analysis of DESs as replacements for organic solvents in drug discovery processes.
• Evaluation of DESs in biocatalytic and traditional chemical synthesis for pharmaceuticals.

Main Results:

• Deep eutectic systems (DESs) present a viable, eco-friendly alternative to traditional organic solvents.
• DESs improve process efficiency, simplicity, speed, and recyclability in drug synthesis.
• The adoption of DESs can lead to reduced production costs and a decreased environmental footprint in the pharmaceutical industry.

Conclusions:

• Deep eutectic systems are promising green solvents for sustainable drug discovery and manufacturing.
• DESs offer a pathway to reduce the environmental impact of the pharmaceutical sector.
• Further integration of DESs in pharmaceutical processes is encouraged for economic and ecological benefits.