Cardiodilatin-immunoreactive neurons in the hypothalamus of Tupaia

Using various region specific antibodies raised against partial sequences of synthetic cardiodilatin (CDD) we detected immunoreactive neurons with their perikarya in the nucleus periventricularis of Tupaia belangeri. The fibers could be traced laterally directed towards the amygdaloid complex and some varicosities were also observed in the lateral parts of the nucleus periventricularis. It is postulated that brain CDD represents a new neuropeptide and that these CDD-IR neurons are involved in specific functions related to the modulation of the cardiovascular centers.