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Development of Biocompatible Digital Light Processing Resins for Additive Manufacturing Using Visible Light-Induced

Mauricio A Sarabia-Vallejos1, Scarleth Romero De la Fuente2,3, Pamela Tapia2

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|February 24, 2024
PubMed
Summary

Researchers developed a novel 3D printing resin for bone scaffolds. Incorporating gyroid structures and bioactive particles significantly improved mechanical strength and osteogenic differentiation for enhanced bone healing.

Keywords:
DLP resinRAFT polymerizationbioceramicsbone scaffoldphotoabsorbers

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • 3D Printing Technology

Background:

  • Bone diseases and injuries pose significant health challenges, exacerbated by aging and obesity.
  • Existing bone defect treatments often struggle to meet the body's natural healing capacity.
  • Advanced materials are needed for effective bone defect repair and regeneration.

Purpose of the Study:

  • To develop a novel 3D printable resin for enhanced bone scaffold applications.
  • To improve the mechanical properties, biocompatibility, and bioactivity of 3D printed bone scaffolds.
  • To investigate the impact of triply periodic minimal surfaces (TPMS) and bioactive particles on scaffold performance.

Main Methods:

  • Developed a new DLP (Digital Light Processing) resin using poly(ethylene glycol diacrylate) (PEGDA) and monomers via PET-RAFT polymerization.
  • Incorporated gyroid triply periodic minimal surfaces (TPMS) into 3D printed scaffolds to optimize porosity and mechanical integrity.
  • Introduced bioactive particles (bioceramics) into the resin to enhance biocompatibility and osteogenic differentiation.

Main Results:

  • The gyroid TPMS structure demonstrated superior mechanical resistance (0.94 ± 0.117 and 1.66 ± 0.240 MPa).
  • Inclusion of bioceramic particles increased the bioactivity signal for osteogenic differentiation by 13% compared to control resins.
  • The photoabsorber Rose Bengal improved printing precision and resolution, enabling intricate scaffold designs.

Conclusions:

  • The novel 3D printing resin, enhanced with gyroid TPMS structures and bioactive particles, offers improved mechanical strength and biocompatibility.
  • This advanced material shows significant potential for creating effective bone scaffolds that promote osteogenic differentiation and bone regeneration.
  • The study highlights the successful integration of advanced structural design and bioactive components for next-generation orthopedic applications.