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Polyvinyl Alcohol, a Versatile Excipient for Pharmaceutical 3D Printing
Nadine Couți1, Alina Porfire1, Rareș Iovanov1
1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", 400012 Cluj-Napoca, Romania.
Polymers
|February 24, 2024
Summary
This review explores polyvinyl alcohol (PVA) for 3D printed pharmaceuticals, focusing on fused deposition modeling (FDM). It highlights PVA
Area of Science:
- Pharmaceutical technology
- Materials science
- Additive manufacturing
Background:
- Three-dimensional (3D) printing enables diverse pharmaceutical dosage forms, including personalized medicines.
- Selecting appropriate excipients is crucial for 3D printing techniques.
- Polymers are primary materials, with polyvinyl alcohol (PVA) widely used in fused deposition modeling (FDM).
Purpose of the Study:
- To review the properties and applications of pharmaceutical-grade PVA in 3D printed dosage forms.
- To focus on PVA utilization within fused deposition modeling (FDM) technology.
- To demonstrate overcoming formulation and processing challenges for optimized drug delivery.
Main Methods:
- Literature review of pharmaceutical-grade PVA properties.
- Analysis of PVA's application in various 3D printing techniques, especially FDM.
- Examination of formulation and processing strategies for PVA-based dosage forms.
Main Results:
- Pharmaceutical-grade PVA exhibits suitable physical and chemical properties for 3D printing.
- PVA is versatile for creating diverse dosage forms via FDM.
- Strategies exist to address formulation and processing challenges with PVA.
Conclusions:
- Polyvinyl alcohol is a key polymer for 3D printed pharmaceutical dosage forms, particularly using FDM.
- Careful formulation and processing enable the creation of tailored drug delivery systems with PVA.
- 3D printing with PVA offers significant potential for personalized medicine and advanced drug release profiles.
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