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Related Concept Videos

Crystal Field Theory - Octahedral Complexes02:58

Crystal Field Theory - Octahedral Complexes

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Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
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X-ray Crystallography02:18

X-ray Crystallography

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The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
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Crystal Field Theory - Tetrahedral and Square Planar Complexes02:46

Crystal Field Theory - Tetrahedral and Square Planar Complexes

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Tetrahedral Complexes
Crystal field theory (CFT) is applicable to molecules in geometries other than octahedral. In octahedral complexes, the lobes of the dx2−y2 and dz2 orbitals point directly at the ligands. For tetrahedral complexes, the d orbitals remain in place, but with only four ligands located between the axes. None of the orbitals points directly at the tetrahedral ligands. However, the dx2−y2 and dz2 orbitals (along the Cartesian axes) overlap with the ligands less than the dxy,...
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Nuclear Fusion02:45

Nuclear Fusion

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The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
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Network Covalent Solids02:18

Network Covalent Solids

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Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
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Additional Subnuclear Structures02:10

Additional Subnuclear Structures

4.6K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Crystal Structures Of Fusion Cores From Ccov-hupn-2018 And Sads-cov.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Crystal Structures Of Fusion Cores From Ccov-hupn-2018 And Sads-cov.

Related Experiment Video

Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae
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Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae

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Crystal Structures of Fusion Cores from CCoV-HuPn-2018 and SADS-CoV.

Fulian Wang1,2, Guang Yang1, Lei Yan1

  • 1Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.

Viruses
|February 24, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

New research reveals the structures of canine coronavirus (CCoV-HuPn-2018) and swine acute diarrhea syndrome coronavirus (SADS-CoV) fusion cores. This structural insight aids in developing broad-spectrum antiviral therapies against emerging coronaviruses.

Keywords:
CCoV-HuPn-2018SADS-CoVX-ray structurecoronavirus

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Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene
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Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene

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Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures
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Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

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Related Experiment Videos

Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae
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Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae

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Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene
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Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene

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Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures
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Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

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Area of Science:

  • Virology
  • Structural Biology
  • Infectious Diseases

Background:

  • Cross-species spillover of coronaviruses (CoVs) from wildlife poses significant global health risks.
  • Canine coronavirus-human pneumonia-2018 (CCoV-HuPn-2018) and swine acute diarrhea syndrome coronavirus (SADS-CoV) are examples of emerging zoonotic CoVs.
  • The Spike protein's fusion core is critical for CoV entry into host cells.

Purpose of the Study:

  • To determine the complete fusion core structures of CCoV-HuPn-2018 and SADS-CoV.
  • To provide a structural basis for developing pan-coronavirus therapeutics.

Main Methods:

  • X-ray crystallography was used to resolve the fusion core structures of CCoV-HuPn-2018 and SADS-CoV.
  • Structural analysis was performed to compare these structures with known CoVs.
post-fusion core

Main Results:

  • The complete fusion core structures of CCoV-HuPn-2018 and SADS-CoV were determined at 2.10 Å and 2.59 Å resolution, respectively.
  • CCoV-HuPn-2018 fusion core structure resembles other Alphacoronaviruses (e.g., HCoV-229E).
  • SADS-CoV fusion core structure is analogous to Betacoronaviruses (e.g., SARS-CoV-2).

Conclusions:

  • The study provides detailed structural insights into the fusion mechanisms of CCoV-HuPn-2018 and SADS-CoV.
  • These findings lay the groundwork for designing pan-coronavirus inhibitors targeting the HR1-HR2 complex.