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Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation
Alessandra Zonari1, Lear E Brace1, Nathaniel H O Harder1
1OneSkin Inc., San Francisco, California, USA.
Introduction:
Senescent cells contribute to age-related tissue deterioration, including the skin, which plays important roles in overall health and social interactions. This study aimed to assess the effects of the senotherapeutic peptide, OS-01 (a.k.a. Pep 14), on skin.
Methods:
A 12-week split-face, double-blinded, vehicle-controlled study involving 22 participants was conducted. The OS-01-containing formulation was applied to one side of the face, while the other side received an identical control formulation lacking the peptide. Skin characteristics were assessed using instrumental measurements, expert clinical grading, and subjective questionnaires.
Results:
Results showed that the OS-01 formulation significantly improved one aspect of skin barrier function, as evidenced by reduced trans-epidermal water loss compared to both baseline and vehicle control. Expert grading and Antera 3D image analysis revealed a reduction in wrinkle appearance and indentation in the periorbital area, and improved skin texture and radiance on both sides of the face, with the OS-01-containing formulation demonstrating superior results. Participants also perceived improvements in skin hydration, smoothness, radiance, and overall appearance.
Conclusion:
The findings suggest that the OS-01 formulation promotes skin health by strengthening the skin barrier, protecting against dehydration, reducing the appearance of wrinkles, and improving skin texture and radiance. These effects are likely attributed to the senotherapeutic properties of OS-01 in reducing cellular senescence and its associated detrimental effects.
Insights
The senotherapeutic peptide OS-01 (Pep 14) formulation improved skin barrier function, reduced wrinkles, and enhanced skin texture and radiance in a 12-week study. This peptide shows promise for promoting skin health and combating aging effects.
Area of Science:
- Dermatology
- Aging Research
- Cosmetic Science
Background:
- Cellular senescence contributes to age-related skin deterioration.
- Senescent cells impact skin health, function, and appearance.
- Targeting senescence offers a novel approach to skin rejuvenation.
Purpose of the Study:
- To evaluate the efficacy of the senotherapeutic peptide OS-01 (Pep 14) on human skin.
- To assess the impact of OS-01 on skin barrier function, wrinkles, texture, and radiance.
- To investigate the potential of OS-01 as a topical anti-aging treatment.
Main Methods:
- A 12-week, split-face, double-blinded, vehicle-controlled study.
- 22 participants applied OS-01 formulation to one side of the face and a control to the other.
- Skin assessments included instrumental measurements, expert grading, and participant questionnaires.
Main Results:
- OS-01 significantly reduced trans-epidermal water loss, improving skin barrier function.
- Reduced wrinkle appearance and indentation were observed, particularly in the periorbital area.
- Improved skin texture, hydration, radiance, and overall appearance were noted, with OS-01 showing superior results.
Conclusions:
- The OS-01 formulation enhances skin health by strengthening the skin barrier and improving hydration.
- OS-01 reduces the visible signs of skin aging, including wrinkles and textural irregularities.
- The senotherapeutic properties of OS-01 contribute to its skin-enhancing effects by mitigating cellular senescence.
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