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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
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Using name overlap analysis to understand medication name search safety.

Allen Flynn1, Katherine D Mieure2, Conor Myers3

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American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
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Medication name overlap in computer systems varies widely, impacting search accuracy. Dynamic, keystroke-responsive searches can improve safety by helping users find the correct drug faster.

Keywords:
automated dispensing cabinetsmedication errorsmedication namesmedication safety

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Area of Science:

  • Pharmacology
  • Health Informatics
  • Human-Computer Interaction

Background:

  • Medication name ambiguity in electronic health records poses a risk for medication errors.
  • Computerized systems often rely on text-based searches for medication identification.

Purpose of the Study:

  • To quantify the extent of left-to-right character overlap in medication names within real-world computerized systems.
  • To assess the implications of this overlap for medication search functionality and safety.

Main Methods:

  • A computational approach was used to analyze character overlap in 20,020 lists of medication names.
  • Lists were generated by random sampling from a database of 2,249 medication names.
  • Analysis focused on lists ranging from 100 to 500 medication names.

Main Results:

  • Maximum left-to-right character overlap ranged from 4 to 29 characters (mode: 14) in general medication lists.
  • For high-alert medications, overlap ranged from 3 to 10 characters (mode: 6).
  • Initial keystrokes are most critical for disambiguating medication names during searches.

Conclusions:

  • Significant variation in medication name overlap necessitates adaptive search strategies.
  • Implementing incremental dynamic search, where systems respond to each keystroke, can enhance medication search safety.
  • This approach may allow users to identify medications with fewer keystrokes, reducing the potential for errors.