Impact of Vitamin C on Inflammatory Response and Myocardial Injury in Sepsis Patients

Area of Science:

• Critical Care Medicine
• Biochemistry
• Pharmacology

Background:

• Sepsis triggers complex inflammatory responses and myocardial injury.
• Investigating therapeutic interventions for sepsis complications is crucial.
• Vitamin C is explored for its potential to mitigate these effects.

Purpose of the Study:

• To assess the impact of vitamin C on inflammatory markers and myocardial damage in sepsis patients.
• To evaluate vitamin C's effect on organ dysfunction and clinical outcomes in sepsis.

Main Methods:

• A randomized controlled trial involving 83 sepsis patients.
• Comparison between a control group (basic treatment) and a study group (basic treatment + vitamin C).
• Assessment of Sequential Organ Failure Assessment (SOFA) scores, inflammatory indices, myocardial injury markers, and mortality rates.

Main Results:

• The vitamin C group showed significantly lower SOFA scores post-treatment (P < .05).
• Key inflammatory markers (hs-CRP, TNF, HMGB1) and myocardial injury markers (CK-MB, cTnI, BNP) were reduced in the vitamin C group (P < .05).
• Morbidity and mortality rates were significantly lower in the vitamin C group (9.52%) compared to the control group (29.27%) (P < .05).

Conclusions:

• Vitamin C supplementation demonstrates significant therapeutic value in sepsis management.
• It effectively reduces inflammatory response, myocardial injury, and improves clinical outcomes.
• Vitamin C enhances treatment efficacy, leading to disease regression and reduced mortality.