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Updated: Jul 2, 2025

Imaging and Analysis of Neurofilament Transport in Excised Mouse Tibial Nerve
Published on: August 31, 2020
Neurofilaments: Novel findings and future challenges
Jessy V van Asperen1, Farah Kotaich1, Damien Caillol1
1ERC Team, NeuroMyoGene Insitute, INMG-PGNM, Inserm U1315, CNRS UMR5261, University of Lyon 1, Lyon, France.
Abstract:
Neurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, particularly their assembly, organisation, transport and degradation. We will emphasise the notion that filaments are not one entity and that future challenges will be to apprehend their diverse composition and structural heterogeneity and to scrutinize how this regulates signalling, sustains neuronal physiology and drives pathophysiology in disease.
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