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Updated: Jul 2, 2025
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
Published on: May 3, 2024
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Pyroptosis-related non-coding RNAs emerging players in atherosclerosis pathology
Weam M A Khojali1, Nasrin E Khalifa2, Farhan Alshammari3
1Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Omdurman 14415, Republic of the Sudan.
Pathology, Research and Practice
|February 24, 2024
Summary
Non-coding RNAs (ncRNAs) significantly regulate pyroptosis, a cell death process, influencing atherosclerosis. Understanding these interactions offers new therapeutic strategies and biomarkers for cardiovascular disease.
Area of Science:
- Cardiovascular Research
- Molecular Biology
- Genetics
Background:
- Atherosclerosis is a major cause of cardiovascular disease, characterized by chronic arterial inflammation.
- Non-coding RNAs (ncRNAs) are key regulators of signaling pathways involved in pyroptosis and the inflammatory milieu of atherosclerotic plaques.
Purpose of the Study:
- To explore the regulatory role of ncRNAs in pyroptosis within the context of atherosclerosis.
- To highlight the potential of ncRNAs as therapeutic targets and biomarkers for cardiovascular conditions.
Main Methods:
- Review of current literature on ncRNAs, pyroptosis, and atherosclerosis.
- Integration of findings from molecular biology techniques and bioinformatics analyses.
- Examination of regulatory networks involving pyroptosis-related ncRNAs.
Main Results:
- ncRNAs critically influence pyroptosis, impacting the inflammatory processes in atherosclerosis.
- Specific ncRNA signatures are associated with atherosclerosis progression.
- Advanced molecular and bioinformatics tools enable detailed study of these regulatory networks.
Conclusions:
- Understanding ncRNA-mediated pyroptosis regulation provides novel insights into atherosclerosis pathophysiology.
- Targeting pyroptosis-related ncRNAs presents a promising avenue for developing new treatments and diagnostic biomarkers for atherosclerosis and related cardiovascular diseases.
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