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Pityriasis Rubra Pilaris: A Multicentric Case Series of 65 Spanish Patients
J Montero-Menárguez1, V Amat Samaranch2, L Puig Sanz2
1Dermatology Department of the Hospital Universitario 12 de Octubre, Madrid, Spain.
Introduction:
PRP is a rare entity of unknown etiopathogenesis. Lack of management guidelines makes it a challenge for clinicians.
Objective:
To add our experience to increase evidence about PRP.
Methods:
We performed a retrospective, descriptive and multicentric study of 65 patients with PRP, being the largest European case series of patients with PRP.
Results:
PRP was more frequent in male patients with an average age of 51 years, but erythrodermic forms presented in older patients (average age 61 years). Six (75%) paediatric patients and ten (60%) non-erythrodermic adults controlled their disease with topical corticosteroids. On the contrary, 26 (68%) erythrodermic patients required biologic therapy as last and effective therapy line requiring an average of 6.5 months to achieve complete response.
Conclusion:
Our study showed a statistical difference in terms of outcome and response to treatment between children or patients with limited disease and patients who develop erythroderma.
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