Related Experiment Video

Updated: Jul 2, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

10.6K

Targeting O-GlcNAcylation in cancer therapeutic resistance: The sugar Saga continues

Lulu Chen1, Mengxue Hu2, Luojun Chen2

  • 1Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, 20057, USA.

Cancer Letters
|February 24, 2024
PubMed

Insights

O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a key nutrient sensor influencing cancer progression and therapy resistance. Targeting this modification shows promise for enhancing cancer treatment efficacy.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic post-translational modification (PTM) crucial for cellular processes.
  • O-GlcNAcylation integrates signals from major metabolic pathways, acting as a nutrient sensor.
  • This PTM influences cancer progression, epigenetic regulation, and therapeutic resistance.

Purpose of the Study:

  • To systematically outline the mechanisms by which O-GlcNAcylation impacts cancer therapy resistance.
  • To discuss the therapeutic potential and challenges of targeting O-GlcNAcylation in cancer treatment.

Main Methods:

  • Literature review and synthesis of existing research on O-GlcNAcylation in cancer.
  • Analysis of O-GlcNAcylation's role in cellular signaling, metabolism, and tumor microenvironment.
  • Evaluation of current strategies targeting O-GlcNAcylation for cancer therapy.

Main Results:

  • O-GlcNAcylation modulates crucial cancer hallmarks including drug efflux, targeting, metabolism, genome stability, EMT, stemness, apoptosis, autophagy, and cell cycle.
  • It influences the tumor microenvironment and immune response.
  • Preclinical studies show O-GlcNAcylation inhibitors enhance therapeutic efficacy.

Conclusions:

  • O-GlcNAcylation is a significant factor in cancer therapy resistance.
  • Targeting O-GlcNAcylation presents a promising therapeutic strategy for improving cancer treatment outcomes.
  • Further research and clinical evaluation are needed to overcome challenges in targeting O-GlcNAcylation.
Keywords:
CancerO-GlcNAcylationOGAOGTTherapeutic resistance

More Related Videos

Glycan Node Analysis: A Bottom-up Approach to Glycomics11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

10.4K
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.2K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
6.9K