[Arterial hypertension in chronic bronchial obstruction and various problems of its treatment]

A total of 127 patients with bronchial asthma of infectious-allergic genesis and chronic obstructive bronchitis were examined for the central and regional hemodynamics as well as for the blood levels of serotonin and monoamine oxidase. The combination of chronic bronchial obstruction with stable "pulmogenic" arterial hypertension was associated with a significantly decreased cardiac index, a reduction in the pulse blood filling of the brain as well as an increase in the peripheral vascular resistance, the pressure in the pulmonary artery, serotonin levels and monoamine oxidase activity. A multiple modality therapy (hydralazin, talinolol, hydrochlorothiazide) elicited an improvement of the hemodynamic and normalization of the biochemical parameters.