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Zonulin and copeptin relation to some metabolic markers in school-aged obese children
Sahar Abd El-Raufe El-Masry1, Rehab A Mahmoud2, Nayera E Hassan3
1Biological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. masrysa@yahoo.com.
Insights
Serum Zonulin and Copeptin levels were evaluated in Egyptian children. Neither biomarker effectively predicts metabolic disturbances like altered lipid profiles or blood pressure in obese youth.
Area of Science:
- Pediatric Endocrinology
- Biomarker Research
- Obesity Studies
Background:
- The role of serum Zonulin and Copeptin as obesity markers in children remains under-investigated.
- Understanding novel biomarkers is crucial for early identification and management of childhood obesity and associated metabolic complications.
Purpose of the Study:
- To assess the association between serum Zonulin and Copeptin levels and obesity indicators in prepubertal Egyptian children.
- To determine the predictive value of Zonulin and Copeptin for metabolic disturbances in obese children.
Main Methods:
- A case-control study included 111 prepubertal Egyptian children (aged 6-10 years), categorized as obese (n=72) or control (n=39) based on BMI percentiles.
- Evaluated anthropometric parameters, blood pressure, body composition, lipid profile, and serum Zonulin and Copeptin levels.
Main Results:
- Obese children exhibited significantly higher Copeptin and lower Zonulin levels compared to controls.
- Zonulin negatively correlated with obesity markers and body composition, while Copeptin showed positive correlations with weight and fat distribution.
- Both Zonulin and Copeptin showed insignificant correlations with blood pressure and lipid profiles.
Conclusions:
- Serum Zonulin and Copeptin are not reliable predictors of metabolic disturbances in obese Egyptian children.
- Further research may explore other potential roles or modified assays for these biomarkers in pediatric obesity.
Background:
Using Zonulin and Copeptin as potential obesity markers in children, hasn't yet been focused.
Aim:
To evaluate the association between serum levels of both Zonulin and Copeptin with the obesity markers, and to assess their role as metabolic disturbance predictors in obese children.
Methods:
A case-control study comprised 111 Egyptian children (45 males and 66 females); aged 6-10 years to avoid the effect of puberty (prepubertal). They were classified according to their body mass index (BMI) percentiles into: 72 obese (BMI ≥ 95th ), and 39 control ones (BMI > 15th - <85th ), based on the Egyptian Growth Charts for children and adolescents. Anthropometric parameters and blood pressure were measured, and body composition analysis, lipid profile, Zonulin, and Copeptin levels were assessed.
Results:
The obese group showed a significantly higher value of Copeptin and a lower value of Zonulin than the control one Also, the obese group showed significant negative correlations between Zonulin and both anthropometric obesity markers and body composition, whereas Copeptin showed significant positive ones. Moreover, significant positive correlations were found between Copeptin and both body weight and fat distribution. Insignificant correlations were observed between both serum Zonulin and Copeptin levels and blood pressure and lipid profile.
Conclusion:
Zonulin and Copeptin cannot be used as metabolic disturbance predictors, among Egyptian children, as they were insignificantly correlated with lipid profile or blood pressure.
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