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Identifying optimal puncture position by a real-time image analysis for Piezo-ICSI: a prospective randomized sibling
Takashi Morimoto1, Tomohiro Maekawa2, Shimpei Mizuta2
1Department of Reproductive Medicine, Reproduction Clinic Tokyo: Shiodome City Center 3F, 1-5-2 Higashi-shimbashi, Minato-ku, Tokyo, 105-7103 Japan..
Reproductive Biomedicine Online
|February 25, 2024
Summary
The intracytoplasmic sperm injection (ICSI) position detector (IPD) significantly reduces oocyte degeneration and unintentional membrane rupture during Piezo-ICSI. This technology enhances embryo availability for fertility treatments by identifying optimal puncture sites.
Area of Science:
- Reproductive Medicine
- Embryology
- Assisted Reproductive Technologies
Background:
- Intracytoplasmic sperm injection (ICSI) is a key technique in assisted reproductive technology.
- Piezo-ICSI, a specific ICSI method, requires precise oocyte puncture.
- Oocyte degeneration and unintentional membrane rupture (UMR) are potential complications during ICSI procedures.
Purpose of the Study:
- To evaluate the efficacy of the intracytoplasmic sperm injection (ICSI) position detector (IPD) in identifying optimal oolemma puncture sites during Piezo-ICSI.
- To determine if IPD use can reduce oocyte degeneration and unintentional membrane rupture (UMR).
Main Methods:
- A sibling oocyte study involving 917 oocytes from 113 patients undergoing Piezo-ICSI.
- Oocytes were randomly assigned to groups with or without IPD.
- Comparison of UMR, degeneration, fertilization, and embryonic development rates between groups.
Main Results:
- The IPD group showed significantly lower rates of UMR (7.0% vs. 12.9%) and degeneration (2.4% vs. 6.1%) compared to the non-IPD group.
- No significant differences were observed in fertilization, blastocyst formation, or good-quality blastocyst rates.
- Pregnancy and live birth rates did not significantly differ between groups.
Conclusions:
- Real-time image analysis using IPD during Piezo-ICSI effectively reduces oocyte degeneration by avoiding high-risk puncture areas.
- IPD may increase the number of viable embryos available for fertility treatments.
- The IPD technology shows promise in improving ICSI procedure safety and efficiency.
