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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

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Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Research progress on the relationship between epilepsy and circRNA.

Jinxia Zhai¹, Chao Wang¹, Liang Jin¹

¹Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

|February 25, 2024

Summary

Circular RNAs (circRNAs) show altered expression in epilepsy, indicating their role in the neurological disorder. These molecules offer potential as epilepsy biomarkers and therapeutic targets.

Keywords:

Circular RNA Diagnostic markers Epilepsy Expression patterns Therapeutic targets

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Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Epilepsy is a chronic neurological disorder characterized by recurrent seizures.
Circular RNAs (circRNAs) are a class of non-coding RNAs with diverse biological functions.

Purpose of the Study:

To comprehensively review the current research on the relationship between epilepsy and circRNAs.
To summarize findings on circRNA expression, diagnostic potential, therapeutic targets, and mechanisms in epilepsy.

Main Methods:

Systematic literature search of the PubMed database.
Review of selected articles focusing on epilepsy and circRNA associations.

Main Results:

Significant alterations in circRNA expression profiles are observed in epilepsy across brain tissues, animal models, and blood.
CircRNAs show potential as diagnostic markers and prognostic indicators for epilepsy.
CircRNAs are emerging as promising therapeutic targets for epilepsy, including gene therapy approaches.

Conclusions:

Dysregulated circRNA expression is implicated in epilepsy pathogenesis and progression.
Specific circRNAs may serve as novel diagnostic and therapeutic targets for epilepsy.
Further research is needed to clarify circRNA functional mechanisms and clinical utility in epilepsy.