Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.2K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Evaluating Flavonoids As Potential Aromatase Inhibitors For Breast Cancer Treatment: In Vitro Studies And In Silico Predictions

Evaluating flavonoids as potential aromatase inhibitors for breast cancer treatment: In vitro studies and in silico predictions

Jeong In Seo1, Jun Sang Yu1, Yonghui Zhang2

  • 1Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea.

Chemico-Biological Interactions
|February 25, 2024

Related Experiment Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.5K
In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
00:05

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

13.9K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K

View abstract on PubMed

Summary
This summary is machine-generated.

Flavonoids show potential as aromatase inhibitors for breast cancer treatment. Several flavonoids demonstrated significant inhibitory activity and favorable drug-like properties, suggesting their development as novel therapeutics.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Aromatase inhibitors are crucial for hormone-dependent breast cancer treatment.
  • Flavonoids offer a promising alternative to current therapies with fewer side effects.

Purpose of the Study:

  • To investigate the in vitro aromatase (CYP19A1) inhibitory potential of 14 different flavonoids.
  • To evaluate the drug-likeness and pharmacokinetic properties of active flavonoids using in silico methods.

Main Methods:

  • In vitro screening of 14 flavonoids for aromatase inhibition.
  • In silico analysis including molecular docking, SwissADME, admetSAR, and QED for drug-likeness prediction.

Main Results:

  • Six flavonoids (pinocembrin, eriodictyol, naringenin, liquiritigenin, sakuranetin, and chrysin) showed IC50 values below 10 μM.
Keywords:
AromataseBreast cancerFlavonoidsInhibitors

Related Experiment Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.5K
In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
00:05

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

13.9K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K
  • These active flavonoids exhibited favorable physicochemical properties and ADME profiles.

    • Conclusions:

    • Pinocembrin, eriodictyol, naringenin, liquiritigenin, sakuranetin, and chrysin are promising candidates for novel flavonoid-based aromatase inhibitors.
    • This research provides valuable insights for developing new breast cancer treatments.