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Psoriasis may increase the risk of idiopathic pulmonary fibrosis: a two-sample Mendelian randomization study

Lingli Chen1, Yujie Wei2, Mengjin Hu3

  • 1Department of Pediatrics, Xiangya Hospital, Central South University, Hunan, 410008, China.

Respiratory Research
|February 25, 2024
PubMed
Abstract

Insights

This study suggests a potential causal link between psoriasis and idiopathic pulmonary fibrosis (IPF). Genetic analysis indicates psoriasis may increase the risk of developing IPF, highlighting the need to understand shared risk factors.

Area of Science:

  • Pulmonary Medicine
  • Dermatology
  • Genetic Epidemiology

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes.
  • Previous studies suggest a possible link between psoriasis and IPF risk, but causal evidence is lacking.

Purpose of the Study:

  • To investigate the potential causal relationship between psoriasis and IPF using a Mendelian randomization (MR) design.
  • To leverage large-scale genome-wide association study (GWAS) data for robust genetic association analysis.

Main Methods:

  • Utilized GWAS data for psoriasis and IPF from European ancestry populations.
  • Employed inverse-variance weighted (IVW) method as the primary analysis.
  • Conducted complementary analyses including weighted median, weighted mode, multivariable MR, and MR-Egger regression to ensure robustness.

Main Results:

  • Genetically predicted psoriasis was significantly associated with an increased odds of IPF (OR=1.09, P=0.02) using the IVW method.
  • Supporting evidence was found with weighted median, weighted mode, and multivariable MR analyses.
  • MR-Egger regression and pleiotropy assessments indicated no significant directional pleiotropic effects.

Conclusions:

  • This MR study provides potential evidence supporting a causal association between psoriasis and IPF.
  • Understanding shared risk factors could improve the clinical management of both psoriasis and IPF.
  • Further research is warranted to elucidate the underlying mechanisms connecting these two conditions.
Keywords:
EpidemiologyIdiopathic pulmonary fibrosisMendelian randomizationPsoriasis

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