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Atypical Hemolytic Uremic Syndrome Triggered by Acute Pancreatitis in a Patient with a Membrane Cofactor Protein

Kosuke Mochizuki1, Naohiro Toda1, Masaaki Fujita2

  • 1Department of Nephrology, Kansai Electric Power Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|February 25, 2024
PubMed

Insights

Atypical hemolytic uremic syndrome (aHUS) can be triggered by pancreatitis in individuals with a specific genetic variant. This case highlights that multiple factors are often necessary for aHUS development.

Area of Science:

  • Nephrology
  • Genetics
  • Hematology

Background:

  • Atypical hemolytic uremic syndrome (aHUS) is a rare, severe thrombotic microangiopathy.
  • Genetic factors, particularly complement gene variants, are implicated in aHUS pathogenesis.
  • The role of environmental triggers in aHUS manifestation remains an area of active research.
Keywords:
MCP variantatypical HUSmultiple hit theorypancreatitis

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