Related Experiment Video
Updated: Jul 2, 2025

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Characterizing Mutational Load and Clonal Composition of Human Blood
Published on: July 11, 2019
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CALR-mutated patients with low allele burden represent a specific subtype of essential thrombocythemia: A study on
Laura Aubin1,2,3, Rúben Vilas Boas4, Rafael Daltro De Oliveira5
1Univ Angers, Nantes Université, CHU Angers, Inserm, CNRS, CRCI2NA, Angers, France.
American Journal of Hematology
|February 26, 2024
Abstract:
A low allele burden (i.e., <20%) of the CALR driver mutation is found in 10.8% of CALR-mutated MPNs, mostly in essential thrombocythemia, and correlates with a milder phenotype and a more indolent evolution compared to patients with an allele burden ≥20%.

