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Updated: Jul 2, 2025

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
MCOCT: an experimentally and numerically validated, open-source Monte Carlo simulator for optical coherence
Khaliun Erdenedalai1, Raphaël Maltais-Tariant1, Mathieu Dehaes2,3,4
1Polytechnique Montreal, Department of Engineering Physics, H3T 1J4, Montreal, Canada.
Abstract:
Here, we present MCOCT, a Monte Carlo simulator for optical coherence tomography (OCT), incorporating a Gaussian illumination scheme and bias to increase backscattered event collection. MCOCT optical fluence was numerically compared and validated to an established simulator (MCX) and showed concordance at the focus while diverging slightly with distance to it. MCOCT OCT signals were experimentally compared and validated to OCT signals acquired in tissue-mimicking phantoms with known optical properties and showed a similar attenuation pattern with increasing depth while diverging beyond 1.5 mm and proximal to layer interfaces. MCOCT may help in the design of OCT systems for a wide range of applications.
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