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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Related Experiment Video

Updated: Jul 2, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

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Acquired Angioedema Associated with Lymphoproliferative Disorders.

Jun Yen Ng1, Meidelynn Ooi1, Samuel K Bennett1

  • 1Department of Hematology, Canberra Hospital, Canberra, ACT, Australia.

Case Reports in Oncology
|February 26, 2024
PubMed
Summary

Acquired angioedema (C1INH-AAE) often indicates underlying B-cell lymphoproliferative disorders (LPDs). Early diagnosis requires comprehensive screening due to often absent symptoms, aiding hematologic malignancy detection.

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Acquired angioedema due to C1 esterase inhibitor deficiency (C1INH-AAE) is frequently linked to lymphoproliferative disorders (LPDs), especially low-grade B-cell types.
Keywords:
B-lymphoproliferative disorderComplementDiagnostic challengeSplenic marginal zone lymphoma

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  • This condition is often underdiagnosed, leading to significant delays in diagnosis due to limited awareness.