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Identifying endoplasmic reticulum stress-related genes as new diagnostic and prognostic biomarkers in clear cell renal cell carcinoma

  • 0Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Translational Andrology and Urology +

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February 26, 2024

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February 26, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Endoplasmic reticulum stress (ERS) is linked to clear cell renal cell carcinoma (ccRCC) progression. This study identified ERS-related genes, with TNFSF13B, APOL1, COL5A3, and CDH5 showing potential as prognostic biomarkers for ccRCC.

Area Of Science

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background

  • Clear cell renal cell carcinoma (ccRCC) is a prevalent and increasing global cancer.
  • Endoplasmic reticulum stress (ERS), arising from protein misfolding, significantly impacts cancer progression and metastasis.
  • Emerging evidence links ERS to the development and advancement of ccRCC.

Purpose Of The Study

  • To identify endoplasmic reticulum stress-related genes for prognostic evaluation in ccRCC.
  • To establish a diagnostic model for ccRCC based on ERS-related genes.
  • To explore the correlation between ERS-related gene expression and clinical characteristics in ccRCC.

Main Methods

  • Utilized transcriptomic data from GEO and TCGA, along with TCGA clinical data.
  • Identified differentially expressed genes (DEGs) related to ERS (ERS-DEGs).
  • Constructed protein-protein interaction (PPI) and gene regulatory networks (miRNA, TF).
  • Developed a diagnostic model using LASSO regression and analyzed prognostic correlations via Cox analysis.

Main Results

  • Identified 11 signature genes and developed a diagnostic model for ccRCC.
  • Confirmed correlations between signature gene expression and clinical characteristics.
  • Found five signature genes (TNFSF13B, APOL1, COL5A3, CDH5) associated with poor ccRCC prognosis.

Conclusions

  • TNFSF13B, APOL1, COL5A3, and CDH5 may serve as potential prognostic biomarkers for ccRCC.
  • These findings offer new insights supporting targeted therapy strategies for ccRCC.
  • The study highlights the role of ERS-related genes in ccRCC pathogenesis and prognosis.

Keywords:

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