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Updated: May 5, 2026

A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Structural aortic wall abnormalities following the Nikaidoh operation, which could be reversible and include a
Magdi H Yacoub1, Ahmed Afifi2, Hatem Hosny2
1Magdi Yacoub Institute, National Heart and lung Institute, Imperial College London, London, UK.
Abstract:
The Nikaidoh operation continues to be used for patients with transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction. We recently reported structural and functional changes in the aortic root during the follow-up of a patient who underwent the Nikaidoh operation. These changes necessitated re-operation. The pathophysiology of these changes and their potential for reversibility have not yet been studied. In this communication, we describe the extensive structural changes in the aortic wall of the same patient.
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