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Lumbar disc herniation is an independent predictor of plaque burden in the patients with unstable angina

Yongchao Wang1, Junhua Ge1, Hao Xu1

  • 1Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Frontiers in Cardiovascular Medicine
|February 26, 2024
PubMed

Insights

Lumbar disc herniation (LDH) is an independent risk factor for coronary atherosclerosis plaque burden. Evolocumab treatment significantly reduced cardiovascular events in patients with LDH and high plaque burden.

Area of Science:

  • Cardiology
  • Neurology
  • Biochemistry

Background:

  • Lumbar disc herniation (LDH) is a common condition.
  • Coronary atherosclerosis is a leading cause of cardiovascular disease.
  • The relationship between LDH and coronary plaque burden is not well understood.

Purpose of the Study:

  • To assess the impact of lumbar disc herniation (LDH) on coronary atherosclerosis plaque burden.
  • To investigate the association between LDH and cardiovascular risk factors.
  • To evaluate the efficacy of evolocumab in treating LDH patients with high coronary plaque burden.

Main Methods:

  • 212 patients with unstable angina undergoing coronary angiography were included.
  • Patients were divided into LDH (n=106) and no LDH (n=106) groups.
  • Gensini scores assessed plaque burden; logistic and Spearman analyses examined associations; Cox regression evaluated evolocumab treatment.

Main Results:

  • LDH patients exhibited higher Gensini scores (P<0.01) and triglycerides (P=0.04), with lower HDL-C (P=0.01).
  • LDH was an independent risk factor for higher Gensini scores (OR=2.38, P<0.01).
  • Evolocumab significantly reduced MACE events (HR=0.26, P=0.04) in LDH patients with high plaque burden.

Conclusions:

  • LDH is an independent risk factor for increased coronary plaque burden.
  • LDH is associated with dyslipidemia, potentially contributing to plaque development.
  • Evolocumab effectively reduces cardiovascular events in LDH patients with high coronary plaque burden.
Abstract

Keywords:
Gensini scoreevolocumab treatmentlumbar disc herniationplaque burdenunstable angina

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