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Trends in gut-heart axis and heart failure research (1993-2023): A bibliometric and visual analysis
Jiahui Ouyang1,2, Lingli Zhao1,2, Yewen Song1
1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Insights
Research on the gut-heart axis and heart failure is rapidly growing. Key areas include gut microbiota, trimethylamine N-oxide, inflammation, and short-chain fatty acids, representing emerging trends in cardiovascular disease research.
Area of Science:
- Cardiovascular Research
- Microbiome Science
- Bibliometrics
Background:
- Heart failure incidence is rising globally due to aging populations.
- The gut-heart axis, involving bidirectional communication, significantly impacts heart failure.
- Understanding this axis is crucial for managing cardiovascular diseases.
Purpose of the Study:
- To conduct a bibliometric analysis of research on the gut-heart axis and heart failure.
- To identify key trends, influential works, and future research directions in this field.
Main Methods:
- Literature search in the Web of Science Core Collection (1993-2023).
- Bibliometric and visualization analyses using CiteSpace, VOSviewer, and R.
- Analysis of publication trends, author contributions, institutions, and keywords.
Main Results:
- 1646 articles published, with a notable increase since 2018.
- USA and China are leading countries; Cleveland Clinic and Charité-Universitätsmedizin Berlin are top institutions.
- "Heart failure," "gut microbiota," "trimethylamine N-oxide," and "inflammation" are prominent keywords.
- Emerging research focuses on "gut microbiota" and "short-chain fatty acids."
Conclusions:
- Research on the gut-heart axis and heart failure is expanding significantly.
- Gut microbiota, trimethylamine N-oxide, inflammation, and short-chain fatty acids are key emerging research areas.
- This analysis provides insights into current research landscapes and future directions for the gut-heart axis in heart failure.
Background:
The incidence of heart failure, the terminal stage of several cardiovascular diseases, is increasing owing to population growth and aging. Bidirectional crosstalk between the gut and heart plays a significant role in heart failure. This study aimed to analyze the gut-heart axis and heart failure from a bibliometric perspective.
Methods:
We extracted literature regarding the gut-heart axis and heart failure from the Web of Science Core Collection database (January 1, 1993, to June 30, 2023) and conducted bibliometric and visualization analyses using Microsoft Excel, CiteSpace, VOSviewer, and the R package "bibliometrix."
Results:
The final analysis included 1646 articles with an average of 35.38 citations per article. Despite some fluctuations, the number of articles published per year has steadily increased over the past 31 years, particularly since 2018. A total of 9412 authors from 2287 institutions in 86 countries have contributed to this field. The USA and China have been the most productive countries, with the Cleveland Clinic in the USA and Charité-Universitätsmedizin Berlin in Germany being the most active institutions. The cooperation between countries/regions and institutions was relatively close. Professor Tang WHW was the most productive author in the field and the journal Shocks published the highest number of articles. "Heart failure," "gut microbiota," "trimethylamine N-oxide," and "inflammation" were the most common keywords, representing the current research hotspots. The keyword burst analysis indicated that "gut microbiota" and "short-chain fatty acids" are the current frontier research topics in this field.
Conclusion:
Research on the gut-heart axis and heart failure is increasing. This bibliometric analysis indicated that the mechanisms associated with the gut-heart axis and heart failure, particularly the gut microbiota, trimethylamine N-oxide, inflammation, and short-chain fatty acids, will become hotspots and emerging trends in research in this field. These findings provide valuable insights into current research and future directions.
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