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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Prodrugs01:30

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
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Routes of Drug Administration: Parenteral01:25

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
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Biopharmaceutics and Pharmacokinetics: Overview01:28

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Advances in peptide-based drug delivery systems.

Sijie Guo1,2, Jing Wang2, Qi Wang1,2

  • 1Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, Shandong, 266112, China.

Heliyon
|February 26, 2024
PubMed
Summary

Functional peptide-based drug delivery systems (DDSs) offer targeted delivery, enhancing drug efficacy and stability. Peptide-drug conjugates (PDCs) show promise for improved biocompatibility and prolonged therapeutic effects.

Keywords:
Application prospectsDrug delivery systemFunctional peptidePeptide-drug coupling

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Area of Science:

  • Biotechnology
  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Drug delivery systems (DDSs) aim to improve therapeutic efficacy by targeting specific sites and minimizing systemic toxicity.
  • Peptides are attractive components for DDSs due to their high affinity, low immunogenicity, and tunable properties.
  • Peptide-drug conjugates (PDCs) leverage peptides to enhance drug biocompatibility and physiological stability.

Purpose of the Study:

  • To review recent advancements in functional peptide-based DDSs.
  • To explore the potential of peptide-based DDSs for targeted delivery of therapeutic agents.
  • To highlight the synergistic effects achievable with functional peptides in drug delivery.

Main Methods:

  • Literature review of recent domestic and international research on peptide-based DDSs.
  • Analysis of peptide properties relevant to drug conjugation and targeted delivery.
  • Examination of applications in delivering anti-cancer and nucleic acid-based drugs.

Main Results:

  • Peptide-based DDSs, particularly PDCs, demonstrate improved in vivo drug stability and prolonged half-life.
  • These systems ensure higher drug concentrations at targeted sites, reducing degradation.
  • Functional peptides enhance the overall performance and specificity of drug delivery.

Conclusions:

  • Peptide-based DDSs represent a promising frontier in targeted drug delivery.
  • Further development is expected to maximize the synergistic potential of functional peptides.
  • These systems hold significant promise for improved therapeutic outcomes in various applications.